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They are either derived from the opium poppy (such as morphine) or are synthesised in a laboratory (such as pethidine or meperidine, anileridine, fentanyl, alfentanil, sufentanil, and remifentanil).
These medications work specifically to weaken or relax most of the (voluntary) muscles of the body. However, they do not affect the muscles of the heart, nor those of the intestines. Before muscle relaxants were introduced in the 1940s, patients had to be given large amounts of anaesthetic medications to ensure that they were deeply anaesthetised. This was necessary to cause their muscles to relax so that the surgeon could operate within the abdomen, or perform other delicate surgery. Now, with the use of muscle relaxants, patients do not have to receive very large amounts of anaesthetic medications nor be so deeply anaesthetised. This helps to reduce the side-effects of anaesthesia. Muscle relaxants include suxamethonium (or succinyl choline), pancuronium, atracurium, vecuronium, and rocuronium.